Every time I leave Google+ and duck back into the Twitterverse, I get frustrated at a few things:
1) Lack of stickiness. It is way too easy to miss posts. I have a bunch of Twitter lists that help, but I still end up doing a lot of scrolling. Messages that can fit in what G+ message are only broken up into dozens of tweets, filling my stream. This also has the opposite effect - if I tweet, I usually get all of the responses that I'm going to get within an hour or so. My G+ posts get responses, likes, and shares days after I post them.
2) Spammers. I'm sure G+ will get its fair share of spammers and bots, but I haven't seen any yet. I hate when i get an @ reply based on one of my posts matching some random bot algorithm.
3) Lack of visualization. Twitter's stream of text is beginning to look boring. I really, really love how visual G+ is, with pics and videos (yes, and animated Gifs) right in the browser.
These are issues that I learned to deal with before Google+, mainly because Twitter is so much better than alternatives like Facebook when it comes to having a conversation. But now, they stick out like a sore thumb.